Characterization of dipalmitoylphosphatidylcholine liposomes containing a soybean‐derived sterylglucoside mixture by differential scanning calorimetry, Fourier transform infrared spectroscopy, and enzymatic assay
Identifieur interne : 001135 ( Main/Exploration ); précédent : 001134; suivant : 001136Characterization of dipalmitoylphosphatidylcholine liposomes containing a soybean‐derived sterylglucoside mixture by differential scanning calorimetry, Fourier transform infrared spectroscopy, and enzymatic assay
Auteurs : Kazuyuki Shimizu [Japon] ; Yoshie Maitani [Japon] ; Kozo Takayama [Japon] ; Tsuneji Nagai [Japon]Source :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1996-07.
Abstract
Previously, we reported that dipalmitoylphosphatidylcholine liposomes (DPPC‐liposomes) containing soybean‐derived steryl glucoside mixtures (SG) (DPPC/SG‐liposomes) accumulated in the liver, especially in parenchymal cells. DPPC/SG‐liposomes and a mixture of DPPC and SG (DPPC/SG mixture) were compared by means of differential scanning calorimetry, Fourier transform infrared (FT‐IR), and enzymatic assays. The results suggested that the maximum molar mixing ratios of DPPC and SG in a powder was DPPC:SG = 7:2.2. Enzymatic assays indicated that the glucose group of SG projected outward from the liposomal surface and that the amount of SG on the liposomal surface was limited, the maximum mole fraction of SG in DPPC/SG‐liposomes being 0.27 (DPPC: SG = 7:2.6). FT‐IR spectra indicated that the glucose group of SG interacts with the phosphate group of DPPC on the surface of liposomes, since the phosphate symmetric and asymmetric stretching bands of DPPC/ SG‐liposomes were shifted to lower frequencies with increasing SG. These results suggested that the glucose group of SG projecting outward from the liposomal membrane contributes to the hepatic cellular distribution of DPPC/SG‐liposomes.
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DOI: 10.1021/js950426p
Affiliations:
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Pharm. Sci.</title><idno type="ISSN">0022-3549</idno><idno type="eISSN">1520-6017</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1996-07">1996-07</date><biblScope unit="volume">85</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="741">741</biblScope><biblScope unit="page" to="744">744</biblScope></imprint><idno type="ISSN">0022-3549</idno></series><idno type="istex">1AA36C13106DEBD5E622301A2F75E81C087B3611</idno><idno type="DOI">10.1021/js950426p</idno><idno type="ArticleID">JPS12</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3549</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previously, we reported that dipalmitoylphosphatidylcholine liposomes (DPPC‐liposomes) containing soybean‐derived steryl glucoside mixtures (SG) (DPPC/SG‐liposomes) accumulated in the liver, especially in parenchymal cells. DPPC/SG‐liposomes and a mixture of DPPC and SG (DPPC/SG mixture) were compared by means of differential scanning calorimetry, Fourier transform infrared (FT‐IR), and enzymatic assays. The results suggested that the maximum molar mixing ratios of DPPC and SG in a powder was DPPC:SG = 7:2.2. Enzymatic assays indicated that the glucose group of SG projected outward from the liposomal surface and that the amount of SG on the liposomal surface was limited, the maximum mole fraction of SG in DPPC/SG‐liposomes being 0.27 (DPPC: SG = 7:2.6). FT‐IR spectra indicated that the glucose group of SG interacts with the phosphate group of DPPC on the surface of liposomes, since the phosphate symmetric and asymmetric stretching bands of DPPC/ SG‐liposomes were shifted to lower frequencies with increasing SG. These results suggested that the glucose group of SG projecting outward from the liposomal membrane contributes to the hepatic cellular distribution of DPPC/SG‐liposomes.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Shimizu, Kazuyuki" sort="Shimizu, Kazuyuki" uniqKey="Shimizu K" first="Kazuyuki" last="Shimizu">Kazuyuki Shimizu</name></region><name sortKey="Maitani, Yoshie" sort="Maitani, Yoshie" uniqKey="Maitani Y" first="Yoshie" last="Maitani">Yoshie Maitani</name><name sortKey="Nagai, Tsuneji" sort="Nagai, Tsuneji" uniqKey="Nagai T" first="Tsuneji" last="Nagai">Tsuneji Nagai</name><name sortKey="Takayama, Kozo" sort="Takayama, Kozo" uniqKey="Takayama K" first="Kozo" last="Takayama">Kozo Takayama</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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